BMAL1 (Phospho-Ser42) Rabbit Polyclonal Antibody - BT-AP00807

BMAL1 (Phospho-Ser42) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00807-20, BT-AP00807-50, BT-AP00807-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1| PER2| PER3) and Cryptochrome (CRY1| CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility| problems with gluconeogenesis and lipogenesis| and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Research Areas: Cardiovascular; Epigenetics and nuclear signaling; Metabolism; Neuroscience

Target Protein: ARNTL

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: BMAL1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O00327; Mouse: Q9WTL8; Rat: Q9EPW1

Synonyms: BMAL1;Ser42; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3

GeneID: Human: 406; Mouse: 11865; Rat: 29657

Research Use Only