BMAL2 Polyclonal Antibody-GCP77

BMAL2 Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: GCP77-50, GCP77-100

Sizes: 50µl, 100µl

Swiss-Prot: Q8WYA1

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

Background: BMAL2, also known as ARNTL2 (aryl hydrocarbon receptor nuclear translocator-like 2), MOP9, CLIF or PASD9, is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BMAL2 polyclonal antibody detects endogenous levels of BMAL2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of BMAL2 polyclonal antibody at 1:2000 dilution
Lane 1: A549 whole cell lysate (40ug)
Lane 2: U-87MG whole cell lysate (40ug)
Lane 3: PC3 whole cell lysate (40ug), Immunohistochemistry of paraffin-embedded Human Brain using BMAL2 antibody at dilution of 1:50.

Bioworld Molecular Weight: ~ 70 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; Brain and muscle ARNT-like 2; CYCLE-like factor; CLIF; Class E basic helix-loop-helix protein 6; bHLHe6; Member of PAS protein 9; PAS domain-containing protein 9

Immunogen: Synthetic peptide, corresponding to Human BMAL2.

Conjugate: Unconjugated

Modification: Unmodified