Bmi-1 Rabbit Polyclonal Antibody (F270) - RA22428

Bmi-1 Rabbit Polyclonal Antibody (F270)

Sizes: 50μL, 100μL

Catalogue Numbers: RA22428-50, RA22428-100

Citations, Manuals and MSDS Available upon request.

Background: BMI1 proto-oncogene, polycomb ring finger (BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1) . This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) ; YM3799

Applications: WB

Species Cross-Reactivity: Human

GeneID (Human): 100532731

Protein MW (KDa): 37-43

SWISS: P35226

Source: Rabbit

Research Use Only