Product Description

BMP-7 (E173) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3674-50, BS3674-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Bone morphogenetic proteins (BMPs) were first identified as molecμles that can induce ectopic bone and cartilage formation. BMPs belong to the TGF-β superfamily, playing many diverse functions during development. BMPs are synthesized as precursor proteins and then processed by cleavage to release the C-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5, and 8), resμlting in the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems.BMP7, also known as osteogenic protein-1 (OP-1), is found to be upregμlated in some cancer cells, and may play a role in cancer metastasis.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, INN: Eptotermin alfa

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human BMP-7.

Dilution: WB: 1:1000~1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BMP-7 (E173) polyclonal antibody detects endogenous levels of BMP-7 protein.

Molecular Weight: ~ 52 kDa

Pathway: TGFβ Smad signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P18075

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only