Product Description

BMP10 Polyclonal Antibody

Catalogue Numbers: BS5628-50, BS5628-100

Sizes: 50µl, 100µl

Alternative Name: Bone morphogenetic protein 10; BMP-10

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O95393

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BMP10 polyclonal antibody detects endogenous levels of BMP10 protein.

Bioworld Molecular Weight: ~ 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of BMP10 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 282-327 of Human BMP10.

Conjugate: Unconjugated

Modification: Unmodified