BMX Monoclonal Antibody - BT-MCA2861

BMX Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2861-50, BT-MCA2861-100

Citations, Manuals and MSDS Available upon request.

Background: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

Research Areas: Signal Transduction

Target Protein: BMX

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1C6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: BMX

Immunogen: Purified recombinant fragment of human BMX expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 78kDa

UniProt Accession: P51813

Synonyms: ETK, PSCTK2, PSCTK3, BMX

GeneID: 660

Research Use Only