Product Description

BOB1 Monoclonal Antibody

Catalogue Numbers: MB67118-50, MB67118-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q16633

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: B cell Oct binding factor-1 (BOB-1/OBF-1) is a B cell restricted transcriptional coactivator. BOB-1 facilitates transactivation of immunoglobulins and other B cell specific genes through the binding and activation of the transcription factors Oct-1 and Oct-2. Research studies have demonstrated that BOB-1 expression is required for antigen-dependent B cell maturation. In pathological conditions such as classical Hodgkin disease, loss of BOB-1 expression is thought, in part, to contribute to the defect in immunoglobulin gene expression by Hodgkin and Reed Sternberg cells. In the context of multiple myeloma, overexpression of BOB-1 has been shown to contribute to malignant plasma cell growth, in part, through enhanced transactivation of TNFRSF17/BCMA.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of BOB1 protein.

Extra Notes: Western blot analysis of BOB1 expression in Daudi (A) whole cell lysates.

Bioworld Molecular Weight: ~ 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: OBF1; POU domain class 2-associating factor 1; B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1

Immunogen: Recombinant fusion protein of human BOB1. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified