BPTF Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA10863-50, RA10863-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: bromodomain PHD finger transcription factor (BPTF) Homo sapiens This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome Reactivity: Human Host: Mouse Applications: WB, ELISA Alternate Names: BPTF, FAC1, FALZ, Nucleosome-remodeling factor subunit BPTF, Bromodomain and PHD finger-containing transcription factor, Fetal Alz-50 clone 1 protein, Fetal Alzheimer antigen Clonality: Monoclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Human Gene ID: 2186 Research Use Only