BPTF Monoclonal Antibody - RA10863

BPTF Monoclonal Antibody Size: 50μL, 100μL Catalogue Numbers: RA10863-50, RA10863-100 Citations, Manuals and MSDS Available upon request. Background: bromodomain PHD finger transcription factor (BPTF) Homo sapiens This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Storage Instructions: -20°C/1 year Applications: WB; ELISA Species Cross-Reactivity: Human GeneID (Human): 2186 SWISS: Q12830 Source: Mouse Research Use Only