BRCA2 Polyclonal Antibody - E-AB-40288

BRCA2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-40288-60, E-AB-40288-120, E-AB-40288-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: BRCA2

Target Synonym: BRCA 2; BRCC 2; Breast and ovarian cancer susceptibility gene early onset antibody; BROVCA2; FACD; FAD 1; FANCB; GLM3

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Rat

Application: WB, IHC, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P51587

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Concentration: 1 mg/mL

Immunogen: Recombinant Human Breast cancer type 2 susceptibility protein

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Antigen Affinity Purification

Dilution: WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400

Calculated MW: 384 kDa

Observed MW: 384 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only