BRCA2 rabbit pAb - ES7290

BRCA2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7290-50, ES7290-100

Citations, Manuals and MSDS Available upon request.

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],

Alternate Name: BRCA2; FACD; FANCD1; Breast cancer type 2 susceptibility protein; Fanconi anemia group D1 protein

Source: Rabbit

Applications: IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human BRCA2. AA range:31-80

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 675

Human SWISS Prot NO: P51587

Subcellular Location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with ERCC5/XPG to nuclear foci following DNA replication stress.

Research Use Only