Product Description

BRMS-1 (E43) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2144-50, BS2144-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9HCU9

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Breast cancer metastasis-suppressor 1 (BRMS1) acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NFκB activity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of BRMS-1 (E43) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 28 kDa

Specificity: BRMS-1 (E43) polyclonal antibody detects endogenous levels of BRMS-1 protein

Alternative Name: Breast cancer metastasis-suppressor 1; BRMS1; BRMS 1

Immunogen: Synthetic peptide, corresponding to amino acids 210-58 of Human BRMS-1.

Conjugate: Unconjugated

Modification: Unmodified