Product Description

BRN3B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65972-50, BS65972-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU (Pit-Oct-Unc) domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. While Brn-3a and Brn-3c stimμlate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regμlate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus and one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development and differentiation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

Host: Rabbit

Applications: IHC-P

Alternate Names: BRN3B, class 4, transcription factor 2, Brain specific homeobox/POU domain protein 3B, Brain-3B, Brain-specific homeobox/POU domain protein 3B, Brn-3B, BRN3.2, Brn3b POU domain transcription factor, PO4F2_HUMAN, POU class 4 homeobox 2, POU domain, POU domain class 4 transcription factor 2, POU domain protein, POU4F2.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human BRN3B:301-400/409

Dilution: IHC-P=1:100-500

Purification: affinity purified by Protein A

Specificity: BRN3B Polyclonal Antibody detects endogenous levels of BRN3B protein.

Molecular Weight: 41kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12837

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only