BTBD6 Polyclonal Antibody - BT-AP00999

BTBD6 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00999-20, BT-AP00999-50, BT-AP00999-100

Citations, Manuals and MSDS Available upon request.

Background: BTBD6 (BTB/POZ domain-containing protein 6), also known as BDPL or lens BTB domain protein, is a 410 amino acid protein that contains one BTB/POZ domain and is specifically expressed in the lens. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD6 may play a role in transcription regulation in the lens.

Research Areas: Cell Biology

Target Protein: BTBD6

Applications: WB, IHC-p, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: BTBD6 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 45925

UniProt Accession: Human: Q96KE9; Mouse: Q8K2J9

Synonyms: BTBD6; BDPL; BTB/POZ domain-containing protein 6; Lens BTB domain protein

GeneID: Human: 90135; Mouse: 399566

Research Use Only