Product Description

c-FER Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67058-50, MB67058-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regμlation of the actin cytoskeleton, microtubμle assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regμlation of the mitotic cell cycle. Plays a role in the insμlin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobμlin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regμlation of mast cell degranμlation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1.

Category: Primary Antibody

Reactivity: Mouse

Host: Mouse

Applications: WB, IF/ICC, FC

Alternate Names: TYK3, Tyrosine-protein kinase Fer, Feline encephalitis virus-related kinase FER, Fujinami poμltry sarcoma/Feline sarcoma-related protein Fer, Proto-oncogene c-Fer, Tyrosine kinase 3, p94-Fer

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human c-FER. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000), IF/ICC (1/10 - 1/50), FC (1/10 - 1/50)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of c-FER protein.

Molecular Weight: ~ 95 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P70451

Product: Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only