Product Description

c-Fms (E557) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1627-50, BS1627-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P07333

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: c-Fms/CSF-1R is a transmembrane tyrosine kinase receptor belonging to the CSF1/PDGF receptor family. It is encoded by the c-Fms proto-oncogene and is expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells and some myoblasts. It is important for growth and differentiation of myeloid cells and its function can be regulated by SLAP-2. c-Fms/CSF-1R is responsible for mediating all of the functions of M-CSF. M-CSF is a glycoprotein required for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF has also been identified as an important mediator of the inflammatory response and can regulate the release of proinflammatory cytokines from macrophages.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of c-Fms (E557) pAb in paraffin-embedded human brain carcinoma tissue at 1:50.

Bioworld Molecular Weight: Predicted band size : 108 kDa
Observed band size : 130 kDa

Specificity: c-Fms (E557) polyclonal antibody detects endogenous levels of c-Fms protein.

Alternative Name: Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen=CD115; CSF1R; FMS

Immunogen: Synthetic peptide, corresponding to amino acids 531-580 of Human c-Fms.

Conjugate: Unconjugated

Modification: Unmodified