Product Description

c-Myb Monoclonal Antibody

Catalogue Numbers: MB66857-50, MB66857-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P10242

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: c-Myb is a transcriptional activator that specifically recognizes the sequence 5'-YAAC[GT]G-3'. It is expressed in hematopoietic progenitor cells where it plays an important role in the control of proliferation and differentiation . c-Myb is required for transcription of genes involved in self-renewal of intestinal stem cells. Importantly, c-Myb regulates expression of Lgr5, a protein expressed in putative intestinal stem cells that give rise to all cell lineages of small intestinal crypts . c-Myb is reported to be expressed in colon crypt cells and in human colorectal cancer lines . Research has shown that c-Myb gene translocations and copy number alterations are found in several leukemias, breast cancer, and other solid tumors .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of c-Myb protein.

Extra Notes: Western blot analysis of c-Myb expression in Jurkat (A), CCRFCEM (B) whole cell lysates.

Bioworld Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Transcriptional activator Myb; Proto-oncogene c-Myb

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human c-Myb. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified