c-Myc Monoclonal Antibody - RA10997

c-Myc Monoclonal Antibody Size: 50μL, 100μL Catalogue Numbers: RA10997-50, RA10997-100 Citations, Manuals and MSDS Available upon request. Background: v-myc avian myelocytomatosis viral oncogene homolog (MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008], Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Storage Instructions: -20°C/1 year Applications: WB; ELISA Species Cross-Reactivity: Human GeneID (Human): 4609 SWISS: P01106 Source: Mouse Research Use Only