c-Myc (phospho Ser373) rabbit pAb - ES6305

c-Myc (phospho Ser373) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6305-50, ES6305-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],

Alternate Name: MYC; BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64

Source: Rabbit

Applications: IHC; IF; IP; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Ser373. AA range:340-389

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 50, (also ~60KD in some samples)

Human Gene ID: 4609

Human SWISS Prot NO: P01106

Subcellular Location: Nucleus, nucleoplasm. Nucleus, nucleolus.

Research Use Only