c-Myc Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA23582-50, RA23582-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: v-myc avian myelocytomatosis viral oncogene homolog (MYC) Homo sapiens The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008], Reactivity: Human Host: Rabbit Applications: WB Alternate Names: MYC, BHLHE39, Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, YM3252 Clonality: Polyclonal Dilution: WB: 1:1000 Molecular Weight: 50, (also ~60KD in some samples) Protein Molecular Weight (kDa): 50, (also ~60KD in some samples) Storage: -20°C/1 year Human Gene ID: 4609 Human SwissProt Number: P01106 Condition: PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide as Preservative and 50% Glycerol. Research Use Only