c-Myc Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A17332-20, A17332-100
Citations, Manuals and MSDS Available upon request.
Background: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.
Category: Polyclonal Antibodies
Applications: WB, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 51kDa
Observed Molecular Weight: 57kDa
Immunogen: Synthetic peptide
Species: Human
GeneID: 4609
SWISS: P01106
Alternate Names: MRTL; MYCC; c-Myc; bHLHe39
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Tumor biomarkers, Signal Transduction, MAPK-Erk Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell differentiation, Cell Cycle Control-G1 S Checkpoint, Endocrine Metabolism, Warburg Effect, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Stem Cells.
NCBI Alias: MYC
Research Use Only