Product Description

CABC1 Polyclonal Antibody

Catalogue Numbers: BS62286-50, BS62286-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8NI60

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background: CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the protein kinase superfamily. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may
be implicated in ubiquinone deficiency, which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CABC1 polyclonal antibody detects endogenous levels of CABC1 protein.

Extra Notes: Western blot analysis of extracts of HL-60 cell line, using CABC1 polyclonal antibody.

Bioworld Molecular Weight: ~ 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Atypical kinase COQ8A, mitochondrial; Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Coenzyme Q protein 8A; aarF domain-containing protein kinase 3; COQ8A; ADCK3; CABC1; PP265

Immunogen: Synthetic peptide, corresponding to Human CABC1.

Conjugate: Unconjugated

Modification: Unmodified