Product Description

CACNA1C Polyclonal Antibody

Catalogue Numbers: BS60266-50, BS60266-100

Sizes: 50µl, 100µl

Alternative Name: Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; Voltage-gated calcium channel subunit alpha Cav1.2; CACNA1C; CACH2, CACN2, CACNL1A1, CCHL1A1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13936

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Voltage-dependent Ca++ channels mediate Ca++ entryinto excitable cellsin response to membrane depolarization, and they are involved in a variety of Ca++-dependent processes, includingmuscle contraction, hormone or neurotransmitter release and gene expression. Calciumchannels are highly diverse,multimericcomplexescomposed of anα-1 subunit, an intracellular β-subunit, a disulfide linkedα-2/δ subunit and a transmembrane γ-subunit. Ca++ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types.L-type Ca++ currentsinitiate muscle contraction, endocrine secretion, and gene transcription, and can be regulated through second-messenger activated protein phosphorylation pathways.L-type calcium channels may form macromolecular signaling complexeswith G protein-coupled receptors, thereby enhancing the selectivity of regulating specifictargets.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CACNA1C polyclonal antibody detects endogenous levels of CACNA1C protein.

Bioworld Molecular Weight: ~ 249 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CACNA1C polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: H9C2 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CACNA1C.

Conjugate: Unconjugated

Modification: Unmodified