Product Description

CACNA1C Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90161-50, BS90161-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13936(Human) Q01815(Mouse) P22002(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: Dotblot ICC IHC FC

All Applications: DotBlot:1:500-1:1,000
ICC:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Background: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).

Purification and Purity: Peptide affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: CACNA1C polyclonal antibody detects endogenous levels of CACNA1C protein.

Bioworld Molecular Weight: 249 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Dot blot analysis of anti-CACNA1C on PVDF. 1ug, 2ug and 4ug of immunization peptides were given in this test. Anti-CACNA1C antibody was diluted with 1/500., ICC staining CACNA1C in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1, alpha-1 polypeptide, cardiac muscle, isoform 1, L type, CAC1C, CACH 2, CACH2, CACN 2, CACN2, CACNA1C, CACNL1A1, Calcium channel, Calcium channel cardic dihydropyridine sensitive alpha 1 subunit, Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle, Calcium channel voltage dependent L type alpha 1C subunit, CaV1.2, CCHL1A1, DHPR alpha 1, DHPR alpha 1 subunit, LQT8, TS, Voltage dependent L type calcium channel alpha 1C subunit, Voltage dependent L type calcium channel subunit alpha 1C, Voltage gated calcium channel alpha subunit Cav1.2, Voltage gated calcium channel subunit alpha Cav1.2, Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*, Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-gated calcium channel subunit alpha Cav1.2,

Immunogen: Synthetic peptide within human CACNA1C aa 800-880.

Conjugate: Unconjugated

Modification: Unmodified