CACNA2D2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A10267-20, A10267-100
Citations, Manuals and SDS Available upon request.
Background: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: CASVDD; CACNA2D; CACNA2D2
GeneID: 9254
Swiss Prot: Q9NY47
Tested Applications: ELISA, WB
Reactivity: Mouse, Rat
Calculated Molecular Weight: 130kDa
Observed Molecular Weight: 140-160kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:200 - 1:2000
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Neuroscience, Calcium Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse brain, Rat heart, Rat brain
Cellular Location: Membrane, Single-pass Type I Membrane Protein,
Keywords: 9254, sc-34768, sc-66822, CACNA2D2, CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, voltage-dependent calcium channel subunit alpha-2/delta-2, alpha 2 delta calcium channel subunit, calcium channel, voltage-dependent, alpha 2/delta subunit 2, gene 26, voltage-gated calcium channel subunit alpha-2/delta-2, Q9NY47, Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2, Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 2, Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2, Gene 26, Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2, Alpha 2 Delta Calcium Channel Subunit, KIAA0558, sc34768, sc 34768, sc66822, sc 66822
Symbol: CACNA2D2
Category: Polyclonal Antibodies
Research Use Only