CAD (phospho-Ser1859) Rabbit Polyclonal Antibody - RA22630

CAD (phospho-Ser1859) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22630-50, RA22630-100

Citations, Manuals and MSDS Available upon request.

Background: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) Homo sapiens The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000

Alternative Names: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5) ; Aspartate carbamoyltransferase (EC 2.1.3.2) ; Dihydroorotase (EC 3.5.2.3) ]

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 790

Protein MW (KDa): 250

SWISS: P27708

Source: Rabbit

Research Use Only