Cadherin-16 (M810) Polyclonal Antibody-BS2221

Cadherin-16 (M810) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2221-50, BS2221-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75309

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-16, also known as Ksp-Cadherin, is a type I membrane protein which is kidney-specific. Cadherin-16 is expressed exclusively in the basolateral membrane of renal tubular epithelial cells. The human Ksp-cadherin gene (Cadherin-16) maps to chromosome 16q21-proximal 16q22. The mouse Ksp-cadherin gene was localized to a highly syntenic region of distal Chromosome 8

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Cadherin-16 (M810) pAb in paraffin-embedded human kidney carcinoma tissue at 1:50. showing cell membrane staining. Negative control (the right) Using PBS instead of primary antibody,Secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.

Bioworld Molecular Weight: ~ 90 kDa

Specificity: Cadherin-16 (M810) polyclonal antibody detects endogenous levels of Cadherin-16 protein.

Alternative Name: Cadherin 16; Kidney-specific cadherin; Ksp-cadherin; CDH16; UNQ695/PRO1340; CDH 16

Immunogen: Synthetic peptide, corresponding to amino acids 791-840 of Human Cadherin-16.

Conjugate: Unconjugated

Modification: Unmodified