Calpain 1 Polyclonal Antibody-BZ01772

Calpain 1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ01772-50, BZ01772-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P07384

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB IHC ICC IF FC

All Applications: WB: 1:500-1:2000
ICC: 1:50-1:200
IHC: 1:50-1:200
FCM: 1:100

Background: Calpain 1, also designated µ-calpain, is an intracellular calcium-dependent protease that cleaves cyto-skeletal and submembranous proteins. Calpains are nonlysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpain-1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Calpain 1 expression in Human fetal kidney lysate.

Bioworld Molecular Weight: ~ 82 kDa

Specificity: Calpain 1 Antibody detects endogenous levels of total Calpain 1.

Alternative Name: Ca2 activated neutral protease; Calcium activated neutral proteinase 1; Calcium activated neutral proteinase; Calcium activated neutral proteinase small subunit; Calcium dependent protease small subunit 1; Calcium dependent protease small subunit; Calcium-activated neutral proteinase 1; Calpain 1 (mu/I) large subunit; Calpain 1; Calpain 1 catalytic subunit; Calpain 1 large subunit; Calpain Large Polypeptide L1; Calpain Large Polypeptide L1; Calpain mu type; Calpain mu-type; Calpain regulatory s

Immunogen: A synthesized peptide derived from human Calpain 1.

Conjugate: Unconjugated

Modification: Unmodified