Calpain 10 rabbit pAb - ES4603

Calpain 10 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4603-50, ES4603-100

Citations, Manuals and MSDS Available upon request.

Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq,

Alternate Name: CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from the N-terminal region of human Calpain 10.

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 75kD

Human Gene ID: 11132

Human SWISS Prot NO: Q9HC96

Subcellular Location: intracellular, cell, mitochondrion, cytosol, plasma membrane,

Research Use Only