Calpain reg Monoclonal Antibody-MB66799

Calpain reg Monoclonal Antibody

Catalogue Numbers: MB66799-50, MB66799-100

Sizes: 50µl, 100µl

Product: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Host: Mouse

Reactivity: Hamster, Rabbit

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins. Calpains are nonlysosomal, calciumactivated intracellular cysteine proteases. They mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Calpain reg protein.

Extra Notes: Western blot analysis of Calpain reg expression in A431 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CAPN4; CAPNS; Calpain small subunit 1; CSS1; Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit

Immunogen: KLH-conjugated synthetic peptide of human Calpain reg. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified