Calreticulin Rabbit pAb - EA366

Calreticulin Rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: EA366-50, EA366-100

Citations, Manuals and MSDS Available upon request.

Background: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .

Alternate Name: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA

Source: Rabbit

Applications: WB

Dilution: WB 1:500-1, 000

Reactivity: Human, Mouse, Rat

Immunogen: Recombinant Protein

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Polyclonal

Isotype: IgG

Concentration: 1mg/mL

Observed Band (KD): 55kDa

Human Gene ID: 811

Human SWISS Prot NO: P27797

Subcellular Location: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

Research Use Only