Product Description

CaMKV (N217) Polyclonal Antibody

Catalogue Numbers: BS2493-50, BS2493-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8NCB2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:1000~1:2000

Background: The Ca2+/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CAMKV (CaM kinaselike vesicle-associated), also known as 1G5 or VACAMKL, is a 501 amino acid protein that localizes to cytoplasmic vesicles, as well as to the cell membrane, and contains one protein kinase domain. Although a member of the CaMK family, CaMKV is thought to be catalytically inactive, but it may play a role in vesicle function and nervous system development. Multiple isoforms of CaMKV exist due to alternative splicing events. The gene encoding CaMKV maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and CharcotMarie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CaMKV (N217) polyclonal antibody detects endogenous levels of CaMKV protein.

Extra Notes: Western blot (WB) analysis of CaMKV (N217) polyclonal antibody at 1:1000 dilution
Lane1:HEK293T whole cell lysate(40ug)
Lane2:U-87MG whole cell lysate(40ug)
Lane3:PC12 whole cell lysate(40ug)
Lane4:BV2 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: CaM kinase-like vesicle-associated protein; CAMKV

Immunogen: Synthetic peptide, corresponding to amino acids 186-247 of Human CaMKV.

Conjugate: Unconjugated

Modification: Unmodified