cAMP Protein Kinase Catalytic Subunit Polyclonal Antibody-BZ16119

cAMP Protein Kinase Catalytic Subunit Polyclonal Antibody

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16119-50, BZ16119-100

Swiss-Prot: P17612/P22694/P22612

Host: Rabbit

cAMP Protein Kinase Catalytic Subunit Polyclonal Antibody-BZ16119

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-F, IHC-P, ICC/IF, ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/10000

Background: PRKACA (protein kinase cAMP-activated catalytic subunit alpha) encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Purification and Purity: Affinity Purified

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 40 kDa; Observed MW: 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of cAMP Protein Kinase Catalytic Subunit in variousLysates using cAMP Protein Kinase Catalytic Subunit antibody., Western blot analysis of cAMP Protein Kinase Catalytic Subunit in COLO205Lysates using PKAα/β/γ cat antibody.

Alternative Name: PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACB; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta

Immunogen: The antiserum was produced against synthesized peptide derived from human PKA alpha/beta CAT. AA range:166-215

Modification: Unmodified

Conjugate: Unconjugated