Product Description

CAPNS1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS6491-50, BS6491-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Calpain 1 is an intracellμlar calcium-dependent protease that cleaves cyto-skeletal and submembranous proteins. Calpains are nonlysosomal, calcium-activated intracellμlar cysteine proteases. Calpains mediate specific Ca2+-dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regμlatory subunit, designated Calpain reg, and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regμlates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resμlting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Calpain small subunit 1, CSS1, Calcium-activated neutral proteinase small subunit, CANP small subunit, Calcium-dependent protease small subunit, CDPS, Calcium-dependent protease small subunit 1, Calpain regμlatory subunit, CAPNS1, CAPN4, CAPNS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human CAPNS1.

Dilution: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CAPNS1 polyclonal antibody detects endogenous levels of CAPNS1 protein.

Molecular Weight: ~ 28 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P04632

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only