CAPS1 rabbit pAb - ES17862

CAPS1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES17862-50, ES17862-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate (PtdIns (4, 5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human CAPS1 AA range: 1275-1325

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 8618

Human SWISS Prot NO: Q9ULU8

Subcellular Location: Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane; Peripheral membrane protein. Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns (4, 5)P2 over PtdIns (3, 4, 5)P3. Probably localizes to different vesicles compared to CADPS2.

Research Use Only