CARD11 (M12) Polyclonal Antibody-BS2228

CARD11 (M12) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2228-50, BS2228-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9BXL7

Host: Rabbit

Reactivity: Human, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CARD11 polyclonal antibody detects endogenous levels of CARD11 protein.

Bioworld Molecular Weight: ~ 133 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of Carma 1 (M12) pAb at 1:500 dilution
Lane1:K562 whole cell lysate(40ug)
Lane2:The Thymus tissue lysate of Rat(30ug)
Lane3:Myla2059 whole cell lysate(40ug)

Alternative Name: Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1; CARD11; CARMA1

Immunogen: Recombinant full length Human CARD11.

Conjugate: Unconjugated

Modification: Unmodified