Product Description

CARD16 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-17810-60, E-AB-17810-120, E-AB-17810-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CARD16

Target Synonym: CAR16; CARD only domain-containing protein 1; CARD only protein ; CARD16; Caspase recruitment domain family; member 16; Caspase recruitment domain-containing protein 16; Caspase-1 dominant-negative inhibitor pseudo-ICE ; Caspase-1 inhibitor COP; COP; COP1; Pseudo interleukin 1 beta converting enzyme; Pseudo interleukin-1 beta converting enzyme; Pseudo interleukin-1beta converting enzyme ; PSEUDO-ICE

Research Areas: Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q5EG05

Background: Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Concentration: 1.1 mg/mL

Immunogen: Synthetic peptide of human CARD16

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Calculated MW: 23 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only