CASP4 Polyclonal Antibody - E-AB-53537

CASP4 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-53537-60, E-AB-53537-120, E-AB-53537-200 Citations, Manuals and MSDS Available upon request. Abbreviation: CASP4 Target Synonym: Apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; CASP4; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel)-II; ICE(rel)II; ICEREL II; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX Research Areas: Cancer, Cell Biology, Metabolism Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human Application: IHC, ELISA Isotype: IgG Clonality: Polyclonal UNIProt ID: P49662 Background: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. Concentration: 0.7 mg/mL Immunogen: Synthetic peptide of human CASP4 Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 Purification Method: Antigen affinity purification Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000 Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only