Product Description

Caspase-1 P10 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65859-50, BS65859-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene resμlts in five transcript variants encoding distinct isoforms. [provided by RefSeq].

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: caspase-1 isoform alpha p10 subunit, CASP 1, CASP1, Caspase 1 apoptosis related cysteine peptidase, Caspase 1 apoptosis related cysteine protease, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1B convertase, IL1BC, IL1BCE, Interleukin 1 beta convertase, Interleukin 1 beta convertase precursor, Interleukin 1 beta converting enzyme. CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p10.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Caspase 1.

Dilution: WB: 1:500-1:2000
IHC: 1:50-1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of Caspase 1 protein.

Molecular Weight: ~10-55 kDa kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -32°C long term. Avoid freeze-thaw cycles.

SwissProt: P29452

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Research Use Only