Caspase-1 rabbit pAb - ES8461

Caspase-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8461-50, ES8461-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],

Alternate Name: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Source: Rabbit

Applications: IF; WB; IHC; ELISA

Dilution: IF: 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 45kD

Human Gene ID: 834

Human SWISS Prot NO: P29466

Subcellular Location: Cytoplasm. Cell membrane.

Research Use Only