Product Description

Caspase-12 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65665-50, BS65665-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecμles. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticμlum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: UNQ9415, Apoptosis related cysteine protease, CASP 12, casp12, CASP12P1, Caspase 12 pseudogene 1, CASP-12, casp12, caspase 12 (gene/pseudogene), Caspase12, CASPC_HUMAN, OTTHUMP00000207026, OTTHUMP00000207028, OTTHUMP00000207031, OTTHUMP00000207032, OTTHUMP00000219058, UNQ9415.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from the middle of human Caspase-12

Dilution: WB=1:500-2000

Purification: affinity purified by Protein A

Specificity: Caspase-12 Polyclonal Antibody detects endogenous levels of Caspase-12 protein.

Molecular Weight: 46 kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O08736

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only