Product Description

Caspase 14 p10 Polyclonal Antibody

Catalogue Numbers: BS5643-50, BS5643-100

Sizes: 50µl, 100µl

Alternative Name: Caspase14; Caspase-14; CASP-14; Caspase-14 subunit p10; CASP14

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P31944

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Caspase 14 p10 polyclonal antibody recognizes endogenous levels of total caspase-14 protein and the p10 subunit of mature caspase-14.

Bioworld Molecular Weight: ~ 10, 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Caspase 14 p10 polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 cell lysate
Lane 2: Mouse spleen tissue lysate
Lane 3: Rat liver tissue lysate

Immunogen: Synthetic peptide, corresponding to amino acids 163-208 of Human Caspase 14.

Conjugate: Unconjugated

Modification: Unmodified