Caspase-3 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-66940-60, E-AB-66940-120, E-AB-66940-200 Citations, Manuals and MSDS Available upon request. Abbreviation: Caspase-3 Target Synonym: CPP32; CPP32B; SCA-1; Active Caspase 3; CASP3; active Caspase-3; Caspase 3; Caspase-3 p12; caspase-3 Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Mouse, Rat Application: WB, IHC, IF Isotype: IgG Clonality: Polyclonal UNIProt ID: P42574 Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. Concentration: 1mg/mL Immunogen: Recombinant protein of human Caspase-3. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200 Calculated MW: 31kDa Observed MW: 31kDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only