Product Description

Caspase 4 (p10, Cleaved-Ala290) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22725-50, RA22725-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-., function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1., PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8., similarity:Belongs to the peptidase C14A family., similarity:Contains 1 CARD domain., subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit., tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Caspase-4 (CASP-4;EC 3.4.22.57;ICE (rel)-II;Protease ICH-2;Protease TX) [Cleaved into: Caspase-4 subunit 1, Caspase-4 subunit 2]

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 10 42

Protein Molecular Weight (kDa): 10 42

Storage: -20°C/1 year

Human Gene ID: 837

Human SwissProt Number: P49662

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only