Product Description

Caspase-6 (phospho-S257) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4219-50, BS4219-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellμlar apoptotic processes. Upon apoptotic stimμlation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A. The cleavage of this protein causes cell membrane malfunction, membrane blebbing and eventual cell death.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Caspase-6, Caspase6, Caspase 6, CASP-6, poptotic protease Mch-2, Caspase-6 subunit p11, CASP6, MCH2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human Caspase-6 around the phosphorylation site of Serine 257.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Caspase-6 (S257) polyclonal antibody detects endogenous levels of Caspase 6 protein only when phosphorylated at Ser257.

Molecular Weight: ~ 35 kDa

Pathway: Inhibition of Apoptosis,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P55212

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only