Caspase-8 Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11324-20, A11324-100
Citations, Manuals and MSDS Available upon request.
Background: This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Category: Polyclonal Antibodies
Applications: WB, IF/ICC, ELISA
Cross-reactivity: Human, Mouse
Protein Weight: 55kDa
Observed Molecular Weight: 57kDa
Immunogen: Recombinant protein (or fragment)
Species: Mouse
GeneID: 12370
SWISS: O89110
Alternate Names: MACH; Mch5; FLICE; CASP-8; Caspase-8
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IF/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, ErbB-HER Signaling Pathway, Cell Biology & Developmental Biology, Apoptosis, Caspases, Mitochondrial Control of Apoptosis, Inhibition of Apoptosis, Ubiquitin, Death Receptor Signaling Pathway, Endocrine & Metabolism, Immunology & Inflammation, Toll-like Receptor Signaling Pathway, Neuroscience, Neurodegenerative Diseases.
NCBI Alias: Casp8
Research Use Only