Product Description

Caspr2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65669-50, BS65669-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adμlt nervous system possess specialized subcellμlar structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecμle CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: FCM

Alternate Names: Cell recognition molecμle Caspr2, Cntnap2, CNTP2, CNTP2_HUMAN, Contactin-associated protein-like 2.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Caspr2

Dilution: Flow-Cyt=1ug/Test

Purification: affinity purified by Protein A

Specificity: Caspr2 Polyclonal Antibody detects endogenous levels of Caspr2 protein.

Molecular Weight: 145kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9UHC6

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only