Product Description

CaSR (A884) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1729-50, BS1729-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P41180

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: The calcium sensing receptor (CaSR) has been shown to play
a major role in regulating parathyroid hormone secretion and
subsequently influencing the calcium concentration of extracellular
fluids. Based on sequence analysis of cDNA clones
it appears that the CaSR is similar to the 7-transmembranedomain
G-protein-coupled receptor superfamily. Changes in
extracellular calcium are thought to modulate a balance between
proliferation and differentiation in a variety of cell
types. In normal primary keratinocytes and breast epithelial
cells, proliferation is inhibited and elevated extracellular
calcium levels trigger differentiation. Malignant transformations
of these cell types are accompanied by a loss of responsiveness
to the anti-proliferative effects of elevated extracellular
calcium.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of CaSR (A884) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.

Bioworld Molecular Weight: ~ 140 kDa

Specificity: CaSR (A884) polyclonal antibody detects endogenous levels of CaR protein.

Alternative Name: Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor 1; PCaR1; CASR; GPRC2A; PCAR1

Immunogen: Synthetic peptide, corresponding to amino acids 850-900 of Human CaSR.

Conjugate: Unconjugated

Modification: Unmodified