CASR Polyclonal Antibody - RA22754

CASR Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22754-50, RA22754-100

Citations, Manuals and MSDS Available upon request.

Background: calcium sensing receptor (CASR) Homo sapiens The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH) -producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:500-1000 IHC: 1:200-500

Alternative Names: CASR; GPRC2A; PCAR1; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor; PCaR1

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Mouse; Rat

GeneID (Human): 846

Protein MW (KDa): 130

SWISS: P41180

Source: Rabbit

Research Use Only