CAST Polyclonal Antibody - E-AB-14814

CAST Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-14814-60, E-AB-14814-120, E-AB-14814-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CAST

Target Synonym: BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin; ICAL; MGC9402; Sperm BS 17 component; Sperm BS-17 component

Research Areas: Cancer, Cell Biology, Neuroscience

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P20810

Background: The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Concentration: 0.7 mg/mL

Immunogen: Recombinant protein of human CAST

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW: 77kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only