Product Description

Catenin-β (phospho-Y670) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64160-50, BS64160-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Catenin beta-1, Beta-catenin, CTNNB1, CTNNB, OK/SW-cl.35, PRO2286

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human CTNNB1 around the phosphorylation site of Tyrosine 670.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Catenin-β (phospho-Y670) polyclonal antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Tyr670.

Molecular Weight: ~ 85 kDa

Pathway: Hypoxia Signaling, Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of Soluble Factors to EMT, hippo Signaling, Adherens Junction signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P35222

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only